Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 27;10:2030. doi: 10.3389/fimmu.2019.02030

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Kroes, Mariman, Hijdra, Hamstra, van Boxtel, van Putten, de Wit and Pinelli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Interplay between human mo-MΦ and NK cells in the presence of B. pertussis (graphics). B. pertussis activates the NLRP3 inflammasome in human macrophages resulting in the secretion of, amongst others, IL-18 and IL-1β. IL-18 primes the NK cells to produce IFNγ and express IL-2Rα and HLA-DR in response to B. pertussis. Inflammasome activation and the crosstalk between human macrophages and NK cells results in an enhanced proinflammatory response to this pathogen (Made with illustrations from: https://smart.servier.com/).