Figure 1.

Advanced age exacerbates neurological impairment and lung infection poststroke. The following assessments were performed 24 hr after mid‐cerebral artery occlusion induction on young (7–10 weeks) and older (12–15 months) mice: (a) preclinical magnetic resonance imaging (MRI) to assess volume of brain oedema (n = 6/group). Oedema region indicated within yellow outline; (b) neurological assessment (n = 14–16/group); (c) bacteriological analysis of lung homogenates to assess poststroke lung infection (n = 6–8/group). Data represent the mean ± SEM. Significance was determined by Mann–Whitney U test, and a p‐value ≤0.05 was considered statistically significant: *p ≤ 0.05, **p ≤ 0.01