Figure 6.

Stroke results in the translocation of intestinal bacteria for systemic dissemination in older animals. (a) Three hours after mid‐cerebral artery occlusion (MCAO) or sham surgery, young and older mice were orally inoculated with streptomycin‐resistant derivative of the Escherichia coli strain DLL206, at a time point when gut permeability was evident. The (b) caecum, (c) faeces, (d) colon and (e) lung were assessed 24 hr later for the presence and load of streptomycin‐resistant E. coli. n = 5–6/group. Data represent the mean ± SEM (log‐scale). Significance was determined by one‐way ANOVA with post hoc comparison and Holm–Sidak multiple testing correction. A p‐value ≤0.05 was considered statistically significant: *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 and ^§ p ≤ 0.1 considered a significant trend