Table 3.
Enrichment of GO terms for biological processes and molecular function in genes with DMRs
| Category: Term | No. of genes | Fold enrichment | Adjusted p value | Genes with DMRsa |
|---|---|---|---|---|
| Biological process: intracellular signal transduction (GO 0035556) | 30 | 2.8 | 0.002 | GPR182, PRKCZ, CARHSP1, NRBP1, ADCY7, TOLLIP, MAP4K2, MCF2L, DGKA , TIAM2, NSMCE1 , ZAP70, SH2B2, NRG2, AKT3, S100A1, AKT2, SGK1 , ABR, SOCS2 , DEPDC1 , CISH , TNS3, MAST4, KSR2 , RPS6KA2 , FYN, CHN2, TSSK6, KALRN |
| Molecular function: transcription factor activity, sequence‐specific DNA binding (GO 0003700) | 48 | 1.9 | 0.013 | RAI1, ZNF274, E2F8, FOXK2, PAX6, RORC, NFIX, CBFA2T3, ZIC1, TCF7L2 , WT1, ZKSCAN4, FOS, ZGPAT, PRDM15 , HOXA4, ZNF300, PAX8, ETV2, ZNF540, ARNTL2 , HSF4, SIM1, RUNX3 , FOXD4, TFDP1, ZNF577, MAFF, RXRB, GTF2H4, ESR1, TEAD2, RB1 , GRHL2, HMGA1 , GAS7, TP73, STAT3, MYCN, HOXB4 , FOXD4L1, HEYL, BNC1, ZNF418, MGA, IRF2, PBX1, PBX2 |
| Molecular function: transcriptional activator activity, RNA polymerase II core promoter proximal region sequence‐specific binding (GO 0001077) | 19 | 3.1 | 0.014 | CEBPE, FOXK2, ESR1, PAX6, NR4A1 , ZIC1, MEIS1, STAT3, WT1, TP73, FOS, EBF4, BCL11B , PAX8, HEYL, ETV2, TXK, PBX1, SOX18 |
| Molecular function: protein kinase activity (GO 0004672) | 24 | 2.6 | 0.014 | SGK494, OBSCN , PRKCZ, NRBP1, LTK, GTF2H4, MAPKAPK3 , MAP4K2, PKMYT1, TTN, MAP3K6, DDR1, KSR2 , HIPK1, RPS6KA2 , HSPB8, ULK3, LMTK3, TXK, TNK2, TSSK6, AKT3, AKT2, KALRN |
| Molecular function: Rho guanyl‐nucleotide exchange factor activity (GO 0005089) | 10 | 5.0 | 0.025 | OBSCN , ABR, TIAM2, TIAM1, PLEKHG5 , ARHGEF15, ARHGEF10 , MCF2L, FARP2, KALRN |
| Molecular function: RNA polymerase II core promoter proximal region sequence‐specific DNA binding (GO 0000978) | 22 | 2.4 | 0.049 | ZNF536, NACC2 , CEBPE, E2F8, FOXK2, ESR1, PAX6, ZIC1, MEIS1, TCF7L2 , TP73, STAT3, FOS, ZGPAT, SKOR1, BCL11B , PAX8, ETV2, TXK, PBX1, SOX18 , ZNF876P |
a
Genes highlighted in bold contain both hypo‐ and hypermethylated DMRs.