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. 2019 Jul 9;18(5):e13001. doi: 10.1111/acel.13001

Figure 5.

Figure 5

ROCK1 inhibition improves cognitive behaviors in APP/PS1 mice. (a) The graph shows the experimental scheme. Y‐27632 or vehicle was injected intraperitoneally in APP/PS1 and WT littermates every 3 days for 45 days. After 60 days, cognitive behaviors were examined. (b) Escape latency to find the hidden platform in MWM test during the 5‐day training and learning regimen. Two‐way ANOVA followed by Student–Newman–Keuls post hoc analysis (group effect: F 2,75 = 59.60; time effect: F 4,75 = 41.18; group × time effect: F 8,75 = 9.17, p < 0.001). (c) Area under curve (AUC) of escape latency in the training trials (two‐way ANOVA followed by Student–Newman–Keuls post hoc analysis, F 2,8 = 54.95). (d) Swimming distance to find the platform in on Day 5 is shown (one‐way ANOVA followed by Student–Newman–Keuls post hoc analysis F 2,15 = 12.85). (e) The percentage of time in the target quadrant in the probe trials is given (F 2,34 = 3.55). (f) The percentage of swimming distance occurring within the target quadrant is calculated for the probe trials (F 2,34 = 4.83). (g) Representative swim paths of individual mice with indicated genotypes. The gray circle indicates the hidden platform. Data are presented as mean ± SEM. n = 5–7 per group. ***p < 0.001; **p < 0.01; *p < 0.05