Table 1.

Summary results of diagnostic performance of prostate health index for prostate cancer

Category	SEN [95% CI]	SPE [95% CI]	PLR [95% CI]	NLR [95% CI]	DOR [95% CI]	AUC [95% CI]
Overall	0.75 [0.70‐0.79]	0.69 [0.66‐0.73]	2.45 [2.19‐2.73]	0.36 [0.31‐0.43]	6.73 [5.38‐8.44]	0.78 [0.74‐0.81]
ethnicityity
Asian population	0.80 [0.75‐0.84]	0.71 [0.67‐0.75]	2.76 [2.41‐3.15]	0.29 [0.23‐0.36]	9.65 [7.17‐12.99]	0.83 [0.79‐0.86]
Caucasian population population	0.72 [0.66‐0.78]	0.68 [0.62‐0.73]	2.24 [1.97‐2.55]	0.41 [0.34‐0.49]	5.47 [4.33‐6.93]	0.76 [0.72‐0.79]
Study design
Prospective	0.74 [0.68‐0.78]	0.69 [0.65‐0.73]	2.39 [2.12‐2.68]	0.38 [0.33‐0.45]	6.23 [4.99‐7.77]	0.77 [0.73‐0.81]
Retrospective	0.78 [0.70‐0.84]	0.70 [0.64‐0.75]	2.59 [2.05‐3.28]	0.31 [0.22‐0.45]	8.25 [4.66‐14.59]	0.80 [0.76‐0.83]
Sample size
>250	0.74 [0.68‐0.79]	0.71 [0.65‐0.76]	2.54 [2.16‐2.98]	0.37 [0.31‐0.45]	6.87 [5.22‐9.03]	0.79 [0.75‐0.82]
≤250	0.77 [0.69‐0.83]	0.67 [0.64‐0.70]	2.31 [2.04‐2.61]	0.35 [0.26‐0.47]	6.60 [4.43‐9.82]	0.69 [0.64‐0.73]
Sensitivity analysis
Age within 60‐69	0.76 [0.71‐0.80]	0.70 [0.65‐0.75]	2.55 [2.22‐2.94]	0.34 [0.29‐0.41]	7.44 [5.89‐9.39]	0.80 [0.76‐0.83]
Deleting studies with sample size <100	0.75 [0.70‐0.79]	0.69 [0.66‐0.73]	2.44 [2.18‐2.73]	0.37 [0.31‐0.43]	6.68 [5.30‐8.43]	0.78 [0.74‐0.81]
Deleting study with age >70	0.74 [0.69‐0.78]	0.70 [0.66‐0.74]	2.46 [2.18‐277]	0.37 [0.32‐0.44]	6.60 [5.22‐8.34]	0.78 [0.74‐0.81]
Deleting cut‐off value >40 or >50	0.74 [0.68‐0.80]	0.69 [0.63‐0.74]	2.38 [2.03‐2.79]	0.38 [0.31‐0.46]	6.31 [4.76‐8.37]	0.77 [0.74‐0.81]