Table 3.
Name (Trade name) | Company | First FDA approval | Medical uses | ORR | tr-AE (Grade ≥3) (%) | |
---|---|---|---|---|---|---|
PD-L1+ (%) | PD-L1– (%) | |||||
Atezolizumab (Tecentriq) | Roche Genetech | 2016 | Urothelial carcinoma, NSCLC | 26 | 9.5 | 17 |
Avelumab (Bavencio) | Merck Serono and Pfizer | 2017 | Merkel-cell carcinoma | 53.8 | 4.2 | 6.8 |
Durvalumab (Imfinzi) | AstraZeneca | 2017 | Urothelial carcinoma | 31 | 0 | 4.9 |
ORR, objective responsive rate to solid tumor; AE, adverse event; tr-AE, treatment-related adverse event; NSCLC, non-small cell lung cancer.
Data source: highlights of prescribing information for Tecentriq, Bavencio, and Imfinzi. ORR and AE data refer to Apolo et al. (36), Massard et al. (37), McDermott et al. (38), Ning et al. (39).