Table 6.
Mean monthly cost estimates by histology, AJCC stage at diagnosis by treatment modality, and significant predictors of cancer‐attributable costs during the terminal phasea
| N (%) | Total cost (95% CI) | Patient‐liability cost (95% CI) | Cancer‐attributable cost (95% CI) | Cancer‐attributable cost predictors | |||
|---|---|---|---|---|---|---|---|
| Year | Age | Year × age | |||||
| Adenocarcinoma | |||||||
| Stage I | 887 | ||||||
| Best supportive care | 280 (31.6) | $11 530 ($9781‐$13 281) | $901 ($802‐$1001) | $7971 ($6133‐$9809) | |||
| Surgery | 110 (12.4) | $31 038 ($17 293‐$44 783) | $1539 ($1102‐$1977) | $25 662 ($11 751‐$39 573) | |||
| Radiation | 135 (15.2) | $11 499 ($9866‐$13 133) | $1170 ($998‐$1342) | $9245 ($7557‐$10 933) | − | − | + |
| Chemoradiation | 269 (30.3) | $11 856 ($10 630‐$13 082) | $1389 ($1036‐$1241) | $8505 ($7202‐$9808) | |||
| Stage II | 861 | ||||||
| Best supportive care | 117 (13.6) | $5843 ($4790‐$6896) | $588 ($447‐$728) | $3323 ($1978‐$4668) | |||
| Surgery | 95 (11.0) | $16 777 ($11 109‐$22 446) | $1139 ($887‐$1391) | $13 072 ($7234‐$18 910) | |||
| Radiation | 113 (13.1) | $11 117 ($9046‐$13 187) | $1169 ($980‐$1358) | $8530 ($6296‐$10 763) | |||
| Chemoradiation | 331 (38.4) | $12 375 ($11 187‐$13 563) | $1311 ($1207‐$1416) | $9437 (48 162‐$10 713) | + | − | |
| Surgery, chemo, and radiation | 133 (15.5) | $20 289 ($13 969‐$26 608) | $1107 ($589‐$1295) | $16 665 ($10 432‐$22 898) | |||
| Stage III | 967 | ||||||
| Best supportive care | 137 (14.2) | $9505 ($7318‐$11 691) | $736 ($583‐$889) | $7356 ($5171‐$9540) | |||
| Radiation | 97 (10.0) | $13 263 ($10 791‐$15 735) | $1425 ($1210‐$1639) | $11 332 ($8778‐$13 885) | − | ||
| Chemoradiation | 389 (40.2) | $15 456 ($11 061‐$19 850) | $1304 ($1205‐$1403) | $10 083 ($9030‐$11 136) | |||
| Surgery, chemo, and radiation | 156 (16.1) | $17 899 ($13 640‐422 159) | $1295 ($1088‐$1502) | $14 937 (410 563‐$19 312) | |||
| Stage IV | 1618 | ||||||
| Best supportive care | 367 (22.7) | $11 107 ($10 134‐$12 080) | $988 ($907‐$1068) | $8980 ($7960‐$10 000) | |||
| Radiation | 295 (18.2) | $15 742 ($14 453‐$17 032) | $1576 ($1471‐41 680) | $13 533 ($12 254‐$14 813) | |||
| Chemotherapy | 215 (13.3) | $11 960 ($10 772‐$13 147) | $1287 ($1177‐$1396) | $9483 ($8089‐$10 876) | |||
| Chemoradiation | 672 (41.5) | $11 708 ($11 048‐$12 367) | $1380 ($1319‐$1442) | $9178 ($8425‐$9931) | + | − | |
| Squamous Cell Carcinoma | |||||||
| Stage I | 604 | ||||||
| Best supportive care | 149 (24.7) | $12 755 ($10 140‐$15 348) | $880 ($736‐$1023) | $10 681 ($7996‐$13 368) | − | ||
| Radiation | 130 (21.5) | $11 668 ($9764‐$13 574) | $1219 ($1025‐$1413) | $8821 ($6812‐$10 831) | − | ||
| Chemoradiation | 253 (41.9) | $12 094 ($10 666‐$13 521) | $1255 ($1104‐$1255) | $9658 (48 152‐$11 163) | |||
| Stage II | 639 | ||||||
| Best supportive care | 104 (16.3) | $9600 ($6932‐$12 268) | $637 ($487‐$514) | $6885 ($4063‐$9707) | |||
| Radiation | 122 (19.1) | $12 381 ($10 599‐$14 163) | $1406 ($1213‐$1599) | $9877 ($7945‐$11 810) | |||
| Chemoradiation | 279 (43.7) | $11 801 ($10 617‐$12 985) | $1215 ($1092‐$1338) | $8876 ($7601‐$10 152) | − | + | |
| Stage III | 668 | ||||||
| Best supportive care | 115 (17.2) | $13 785 ($11 139‐$16 431) | $991 ($832‐$1160) | $11 746 ($9032‐$14 460) | |||
| Radiation | 130 (19.5) | $14 407 ($12 333‐$16 482) | $1336 ($1156‐$1517) | $12 165 (49 983‐$14 347) | |||
| Chemoradiation | 301 (45.1) | $12 343 ($11 160‐$13 526) | $1306 ($1199‐$1414) | $9908 ($8645‐$11 171) | + | − | |
| Stage IV | 786 | ||||||
| Best supportive care | 180 (22.9) | $13 038 ($11 395‐$14 682) | $1074 ($948‐$1201) | $10 956 ($9300‐$12 613) | − | ||
| Radiation | 199 (25.3) | $17 789 ($15 553‐$20 024) | $1590 ($1410‐$1768) | $15 589 ($13 304‐$17 874) | |||
| Chemoradiation | 301(38.3) | $13 581 ($12 431‐$14 732) | $1395 ($1291‐$1498) | $11 443 ($10 245‐$12 641) | |||
Abbreviation: AJCC, American Joint Committee on Cancer.
a
A positive (+) symbol indicates that the covariate in the regression model has a parameter estimate greater than 0, while a negative (−) symbol indicates that the parameter estimate is less than 0. Treatment modality costs are not shown if less than 10% of patients within a stage/histology group received that treatment.