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. 2019 Jul 6;8(11):5232–5241. doi: 10.1002/cam4.2386

Figure 4.

Figure 4

shRNA‐mediated knockdown of Tyk2 in JW23.3 murine MPNST cells leads to decreased tumor growth in vivo. (A) Dissected tumors from subcutaneous injection of shTyk2‐infected JW23.3 cell lines and control shLacZ. (B) Quantification of subcutaneous tumor volume over time. (C) Quantification of the number of Cleaved Caspase‐3 positive cells from immunohistochemistry of harvested subcutaneous tumors of shTyk2‐infected JW23.3 cell lines and control shLacZ. (D) Representative images of Cleaved Caspase‐3 immunohistochemistry. (E) Tumor burden over time as measured by photon flux in mice injected intraventricularly. (F) Representative images of mice following intraventricular injection. (n = 5 for all groups; *P < 0.05, **P < 0.01, ***P < 0.001)