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. 2019 Sep 2;9:12645. doi: 10.1038/s41598-019-49164-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of DSS-treated colon with standard IHC. (A) The LP infiltrate status was scored as follow: 0 = absence of infiltrating cells; 1 = poor presence of infiltrating cells; 2 = moderate presence of infiltrating cells; 3 = severe presence of infiltrating cells. (B) Epithelial damage was determined evaluating the integrity of the epithelial layer of the enteric mucosa. This parameter was scored as 0 = absence, 1 = low, 2 = moderate; 3 = severe. (C) Representative images of standard IHC of WT and E1 TG treated colon samples for T (CD3) and B (CD45R/B220) lymphocytes and myeloid cells (MPO). Inflammatory cells were scored counting the number of positive cells within the mucosa (excluding cells of lymphoid follicles): 0 = cell absence; 1 = 1–5 cells; 2 = 6–25 cells; 3 = 26–125 cells; 4 > 125 cells. Bar graphs show mean score values ± s.d. from at least three mice individually tested per group. Scale bar = 100 μm.