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. 2019 Sep 2;10:3941. doi: 10.1038/s41467-019-11853-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Longitudinal map for onset of complete biological response in nasopharyngeal carcinoma patients. a Treatment timeline. b The longitudinal cell-free Epstein–Barr virus (cfEBV) DNA responses during induction chemotherapy and concurrent chemo-radiotherapy. c Differential cfEBV DNA response phenotypes characterised by inter-individual variation in complete biological response (cBR) and onset of bounce (a positive cfEBV DNA reading following cBR) (left panel), and characterisation of two types of EBV DNA bounce by biological response post radiotherapy (right panel). Six hundred and seventy-three locally advanced nasopharyngeal carcinoma patients receiving induction chemotherapy and concurrent chemotherapy were included. cBR was defined by undetectable cfEBV DNA level