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. 2019 Aug 27;9:834. doi: 10.3389/fonc.2019.00834

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Copyright © 2019 Ogunwobi and Kumar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LncPVT1 and its associated microRNAs induce chemoresistance in various cancers by regulating oncogenes or tumor suppressor genes. Affected downstream pathways include the TGF-β and PI3K-AKTpathways. Also depicted is epigenetic inhibition of target genes via EZH2.