Table 1.

Key literature of the present review.

Paragraph	Topic	Major references
Host and bacterial determinants in human tuberculosis	Host Genetic polymorphism	-Harishankar et al. (10) - Casanova and Abel (7) - Cobat et al. (8) - Stein et al. (9) - van Tong et al. (11)
	MSMD	-Rosain et al. (12)
	Transcriptomic studies	-Berry et al. (13) - Blankley et al. (14)
	Bacterial Virulence factors	- Forrellad et al. (15)
Innate immune response against Mycobacterium tuberculosis	AECs	- Li et al. (16) - Harriff et al. (17)
	Macrophages	- Queval et al. (18) - Lerner et al. (19) - Yuk et al. (20) - Gröschel et al. (21) - Bustamante et al. (22) - Sia et al. (23) - Sun et al. (24) - Neyrolles et al. (25) - Botella et al. (26)
	Neutrophils	- Kroon et al. (27) - Lowe et al. (28) - Tan et al. (29) - Zhang et al. (30)
	Dendritic cells	- Mihret (31) - Khan et al. (32) - Wu et al. (33) - Balboa et al. (34) - Georgieva et al. (35) - Velasquez et al. (36) - Ehlers (37)
	NK cells	- Esin and Batoni (38) - Arora et al. (39) - Zhang et al. (40)
	Mast Cells	- Garcia-Rodriguez et al. (41) - Carlos et al. (42)
	Complement	- Lubbers et al. (43) - Cai et al. (44)
Adaptive immune response against Mycobacterium tuberculosis	CD4+ T lymphocytes	- Cooper (45) - Sia et al. (46) - Domingo-Gonzalez et al. (47) - Parkash et al. (48) - Sallin et al. (49)
	CD8+ T lymphocytes	- Lin and Flynn (50) - Canaday et al. (51) - Oddo et al. (52)
	Humoral immunity	- Kozakiewicz et al. (53) - Jacobs et al. (54) - Glatman-Freedman and Casadevall (55) - Lu et al. (56)
	Granuloma	- Ramakrishnan (57) - Russell (58) - Reece and Kaufmann (59) - Refai et al. (60) - Martinot (61) - Russell et al. (62)

The major references are grouped basing on the different topics addressed in each paragraph. The most relevant and comprehensive review or study for each topic is highlighted in bold. MSMD, Mendelian Susceptibility to Mycobacterial Disease; AEC, Airway Epithelial Cell; NK, Natural Killer cells.