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. 2019 Aug 27;9:809. doi: 10.3389/fonc.2019.00809

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Copyright © 2019 Feng, Wang, Liu, Li, Zhang, Zhuang, Yao, Liu, Li, Cao, Li, Gong, Li, Zhang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Notch signaling pathways in GHomas. (A) Expression of Notch2, DLL1, DLL3, DLL4, and SSTR2 in invasive and non-invasive GHomas. Brown: positively stained. (B) H-scores of Notch2, DLL1, DLL3, DLL4, and SSTR2. P-values was indicated by * and ** (<0.05 and <0.01). (C) Disease-free survival of patients was indicated to be significantly different according to the DLL3 expression. (D) Expression of Notch signaling between invasive and non-invasive GHomas. There was significant difference of Notch1, Notch2, and DLL3 between invasive and non-invasive based on the density value of bands. Assays were performed in triplicate.