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. 2019 Aug 27;11:225. doi: 10.3389/fnagi.2019.00225

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Copyright © 2019 Xi, Sun, Chen, Chen, Gao, Yin and Jing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blood biochemistry parameters of human islet amyloid polypeptide (hIAPP^−/−) or hIAPP^−/+ mice fed with a high/low-fat diet for 6 or 12 months. (A) Plasma glucose content at 6 months after treatment. (B) Plasma glucose content at 12 months after treatment. (C) Plasma insulin content at 6 months after treatment. (D) Plasma insulin content at 12 months after treatment. (E) Results of the glucose tolerance test (GTT) at 6 months after treatment. (F) Results of the GTT at 12 months after treatment. (G) Results of the insulin sensitivity test at 6 months after treatment. (H) Results of the insulin sensitivity test at 12 months after treatment. L^−/− denotes hIAPP^−/− mice on a low-fat diet; L^+/– denotes hIAPP^+/– mice on a low-fat diet; H^−/− denotes hIAPP^−/− mice on a high-fat diet; H^+/– denotes hIAPP^+/– mice on a high-fat diet. n = 12, *p < 0.05, **p < 0.01, ***p < 0.001 compared with the L^−/− group.