. 2019 Aug 27;9:812. doi: 10.3389/fonc.2019.00812

Table 1.

The prognostic effect of different clinical characteristics.

	Univariate analysis^a			Multivariate analysis^b
	HR	95%CI	P-value	HR	95%CI	P-value
CIMP-status	0.35	0.24–0.5	<0.001	0.29	0.04–2.19	0.232
IDH1-status	0.34	0.21–0.55	<0.001	1.8	0.23–14.08	0.573
MGMT-status	0.69	0.54–0.87	<0.001	0.84	0.64–1.1	0.205
Subtype	0.93	0.86–1.01	0.07	-	-	-
Age	1.03	1.03–1.04	<0.001	1.03	1.02–1.04	<0.001
Gender	1.16	0.96–1.41	0.13	-	-	-
Risk score	1.57	1.3–1.89	<0.001	1.49	1.14–1.94	0.003

These data were used to perform the Cox proportional hazards regression.

Multivariate analysis used stepwise addition of clinical covariates related to survival in univariate analysis (P < 0.01) and the ultimate models contained those covariates that were significantly associated with survival (P < 0.01).