Skip to main content
. 2019 Aug 10;19:647–661. doi: 10.1016/j.isci.2019.08.016

Figure 4.

Figure 4

Genes Differentially Regulated by Virus Infection versus Type I IFN

(A) Heatmap of log2-fold changes in IFN-treated cells as compared with Clone 13-infected cells. The displayed genes were filtered by an absolute log2-fold change of 2 and an adjusted p value < 0.05. Genes that are similarly regulated at 6 and 24 h post IFN are clustered together. Data are averages from three biological replicates. Genes missing a gene name and a function in the current Ensembl annotation of M. lucifugus were listed by their unique and abbreviated ID numbers: e.g., “ENSMLUG00000015795” was shortened to “15795.”

(B) Venn diagrams showing the numbers of significantly regulated mRNAs at the two time points of IFN treatment.

(C) Expression box plots of selected mRNAs that responded significantly to Clone 13 treatment but not to control and IFN-stimulated conditions. The plots show the DESeq2-normalized expression values for each condition and biological replicate. Graphs show mean values and standard deviations from the three biological replicates.