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. 2019 Jun 18;8(3):447–473. doi: 10.1016/j.jcmgh.2019.06.003

Figure 6.

Figure 6

Effects of BAR501 administration on NK and NKT cells. Acute hepatitis was induced in C57BL6 male mice, GPBAR1+/+ and GPBAR1–/–, by intravenous injection of Con A (15 mg/kg) 8 or 24 hours. Mice were randomized to receive Con A alone or in combination with BAR501 (30 mg/kg) daily from 3 days before induction of hepatitis to the time of the sacrifice. Liver tissues were used to perform a detailed characterization of liver infiltrating cells by IC-FACS analysis. Data shown are numbers of (A) NK and (B) NKT cells for milligrams of liver tissue; (C) characterization of proinflammatory (IFN-γ+) and anti-inflammatory (IL-10+) NKT cells; (D) flow cytometry analysis of IFN-γ expression and IL-10 expression in NKT cells recruited into the liver. Results are the mean ± SEM of 7 mice per group. #Wild-type Con A vs knockout Con A; $wild-type Con A vs wild-type Con A + BAR501; §wild-type Con A + BAR501 vs knockout Con A + BAR501. *P < .05.