Table 1.
Plasmatic Levels of AST and ALT and Liver Index (Obtained From Ratio of Liver Weight and Body Weight × 1000)
| GPBAR1+/+ |
GPBAR1–/– |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| NT | 8 h |
24 h |
NT | 8 h |
24 h |
|||||
| α-GalCer | α-GalCer + BAR501 | α-GalCer | α-GalCer + BAR501 | α-GalCer | α-GalCer + BAR501 | α-GalCer | α-GalCer + BAR501 | |||
| AST | 81.1 ± 12.60 | 145.2 ± 122.2 | 107.4 ± 11.01 | 1300 ± 218.0 | 545.8 ± 136.9 | 91 ± 4.000 | 161.3 ± 7.318 | 169.1 ± 15.14 | 2138 ± 964.9 | 2224 ± 423.2 |
| ALT | 38.01 ± 4.371 | 58.54 ± 61.12 | 43.22 ± 4.099 | 1104 ± 253.3 | 445.3 ± 8.803 | 37 ± 3.000 | 62.01 ± 16.3 | 61.1 ± 14.82 | 2356 ± 762.1 | 2321 ± 658.0 |
| Liver Index | 39.47 ± 1.566 | 48.87 ± 2.616 | 43.24 ± 1.217 | 53.8 ± 1.879 | 48.28 ± 0.2271 | 42.53 ± 1.314 | 49.77 ± 1.916 | 48.48 ± 1.056 | 58.37 ± 2.399 | 59.07 ± 2.607 |
Values are mean ± SD.
α-GalCer, α-galactosylceramide; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GPBAR1, G-protein–coupled bile acid receptor 1; NT, not treated.