Table 2.
Plasmatic Levels of AST and ALT in Each Group and Number of Leukocytes in Liver Tissues
| GPBAR1+/+ |
GPBAR1–/– |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| NT | 8 h |
24 h |
NT | 8 h |
24 h |
|||||
| Con A | Con A + BAR501 | Con A | Con A + BAR501 | Con A | Con A + BAR501 | Con A | Con A + BAR501 | |||
| AST | 105.8 ± 16.46 | 5007 ± 1776 | 1271 ± 304.2 | 2812 ± 543.9 | 842 ± 301.1 | 78.92 ± 9.59 | 12183 ± 3696 | 13184 ± 3520 | 9440 ± 4955 | 9011 ± 4829 |
| ALT | 32.44 ± 1.879 | 5066 ± 1509 | 1682 ± 590.9 | 2442 ± 361.4 | 1230 ± 183.3 | 36.31 ± 3.255 | 11043 ± 2322 | 11935 ± 2511 | 9905 ± 3468 | 9170 ± 3595 |
| Leukocytes (106)/ mg of liver | 1.043 ± 0.05937 | 1.386 ± 0.04059 | 1.159 ± 0.08166 | 1.469 ± 0.08061 | 1.697 ± 0.1488 | 1.201 ± 0.05937 | 2.082 ± 0.1462 | 1.834 ± 0.2715 | 2.492 ± 0.5143 | 2.182 ± 0.082 |
Values are mean ± SD.
α-GalCer, α-galactosylceramide; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Con A, concanavalin A; GPBAR1, G-protein–coupled bile acid receptor 1; NT, not treated.