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Formation of larger protein-NP aggregates during multiple solute simulations. (A) Formation of protein-NP oligomers with the NPs intercalating between protein-protein complexes especially by contacting the protein through the apical regions (B) The separated protein-NP complexes are associating into larger aggregates through the NP-NP interaction occurring via protein apical region already covered with NPs. Protein all-atom reconstruction was performed with PULCHRA [25,26].
