Table 1.

Histone lysine demethylases involved in adipogenic development and its relation to obesity.

Chromatin Modifier	Histone Targets	Type of Adipocytes	Roles in Adipose Tissue	Reference
LSD1	H3K4me2, H3K9me2	Brown, Beige, White	The adipose-specific deletion of LSD1 induces an increase in WAT-selective gene expression, impaired oxidative phosphorylation, reduced energy expenditure and increased fat mass.	[23,84]
KDM4B	H3K9me3	Brown, White	Loss of KDM4B impairs energy expenditure, adaptive thermogenesis, and adipose tissue lipolysis, resulting in obesity and associated metabolic dysfunction.	[79,100]
KDM3A	H3K9me1, H3K9me2	Brown, Beige	KDM3A regulates beige and brown adipogenesis by modulating the expression of metabolic genes. The loss of KDM3A function results in obesity and hyperlipidemia in mice.	[78,106]