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. 2019 Aug 15;24(16):2961. doi: 10.3390/molecules24162961

Table 4.

Anionic amino acid derived polymers for pH-responsive drug release.

Type of AA Payload Target/pH Polymer a Ref.
Asp DFS Colon pAsp-l-pNIPAm [146]
5-Fluoruracil Intestine Konjac glucomannan-pAsp hydrogel [147]
Ocular drug Eye Thiolated PAsp [149]
Glutathione or oxytocin Colon Succinic derivative of insulin cross linked pAspHz [152]
DTX Drug resistant cancer cell PEG-b-PAsp [162]
Glu Dox Intracellular tumor mPEG-b-p(LGA-co-CELG) [182]
Adriamycin hydrochloride Tumor pH Star-block-copolymer of PEI, PLGA and PEG [183]
Dox Lysosome PLGA-co-PLA-DPPE [187]

a See abbreviations for definitions of the terms used.