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. 2019 Aug 11;20(16):3905. doi: 10.3390/ijms20163905

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Glucagon control on food intake. Diagram of the neuronal pathway that regulates the anorexigenic action of glucagon. Green arrows indicate an increase or activation, while red arrows indicate a decrease or inhibition. AgRP: Agouti related peptide; AMPK: Adenosine monophosphate -activated protein kinase; AP: Area Postrema; ARC: Hypothalamic arcuate nucleus; BBB: Blood brain barrier; CaMKKβ: Ca2+/calmodulin-dependent protein kinase kinase β; DMH: Dorsomedial hypothalamic nucleus; GCGR: Glucagon receptor; HT: Hypothalamus; LH: Lateral hypothalamic area; NTS: Nucleus tractus solitarius; PKA: Protein kinase A; PVN: Paraventricular hypothalamic nucleus; VMH: Ventromedial hypothalamic nucleus; 3V: Third ventricle. Figure made with Servier Medical Art resources.