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Unimolecular polypharmacy targeting the glucagon receptor: Schematic overview of the effects of polyagonists of glucagon receptor on energy balance regulation. GCG [Glucagon (red)], GIP [glucose insulinotropic peptide (orange)], GLP-1 [Glucagon like peptide-1 (blue)], GLP-1/GCG (purple), and GLP-1/GIP/GCG (green) (right and left panels). Arrows up indicate increase, while arrows down indicate decrease. Figure made with Servier Medical Art resources.
