Changes of ex-miR-125b levels in the PR, SD and PD groups during treatment. Ex-miR-125b levels before chemotherapy and after 1, 2, 3, 6, 9 and 12 months of mFOLFOX6-based chemotherapy were compared among patients with (A) PR, (B) SD and (C) PD. Ex-miR-125b, exosomal microRNA-125b; PR, partial response; SD, stable disease; PD, progressive disease.