Table 4.
Cytokine CD4+ T cell response from Peyer's patches and lamina propria of CD1 mice supplemented with sweeteners for 6 and 12 weeks.
| CL | SUC | Splenda® | Svetia® | ||
|---|---|---|---|---|---|
| Mean±SD | Mean±SD | Mean±SD | Mean±SD | P value∗ | |
| (%) | (%) | (%) | (%) | ||
| 6 weeks of treatment, Peyer's patches | |||||
|
| |||||
| IL-6 | 4.59±0.064 | 2.77±0.08 | 3.52±0.069 | 2.47±0.106 | 0.001∗ |
| IL-17A | 1.15±0.08 | 2.94±0.074 | 3.87±0.058 | 3.33±0.074 | 0.001∗ |
|
| |||||
| 12 weeks of treatment, Peyer's patches | |||||
|
| |||||
| IL-6 | 6.16±0.08 | 8.29±0.053 | 11±0.176 | 8.38±0.053 | 0.001∗ |
| IL-17A | 1.71±0.08 | 4.46±0.235 | 5.04±0.053 | 5.32±0.074 | 0.001∗ |
|
| |||||
| 6 weeks of treatment, Lamina propria | |||||
|
| |||||
| IL-6 | 9.39±0.08 | 10.11±0.053 | 16.01±0.176 | 11.94±0.053 | 0.001∗ |
| IL-17A | 3.85±0.074 | 7.41±0.074 | 7.89±0.058 | 11.15±0.074 | 0.001∗ |
|
| |||||
| 12 weeks of treatment, Lamina propria | |||||
|
| |||||
| IL-6 | 6.16±0.08 | 8.29±0.053 | 11±0.176 | 8.38±0.053 | 0.001∗ |
| IL-17A | 3.36±0.074 | 12.25±0.074 | 12.04±0.058 | 10.17±0.08 | 0.001∗ |
The values represent the mean±SD of percentage of intracellular cytokines of Peyer's patches and lamina propria in mice supplemented with sweeteners. Two-way ANOVA was performed to compare the differences between the groups. The differences were considered statistically significant with p <0.05 ∗.