Table 3.
Associations between the presence, severity, and number of prevalent vertebral fractures and HR-pQCT parameters in women with a recent NVF at the FLS
| Presence of prevalent VFs | Severity of prevalent VFs | ||||
|---|---|---|---|---|---|
| Radius | No VF | VF (β (95% CI)) | Gr. 1 VF (β (95% CI)) | Gr. 2–3 VF (β (95% CI)) | P value for trend |
| vBMD | |||||
| Dtot (mgHA/cm3) | Ref. | − 16.66 (− 31.93, − 1.39)* | − 10.05 (− 28.65, 8.56) | − 26.10 (− 47.65, − 4.56)* | .015* |
| Dtrab (mgHA/cm3) | Ref. | − 11.75 (− 21.91, − 1.58)* | − 7.66 (− 20.06, 4.73) | − 17.57 (− 31.92, − 3.22)* | .012* |
| Dcort (mgHA/cm3) | Ref. | − 9.88 (− 26.38, 6.62) | − 7.58 (− 27.74, 12.58) | − 13.16 (− 36.50, 10.18) | .216 |
| Micro-architecture | |||||
| Tb.N (1/mm) | Ref. | − 7.83 (− 15.19, − 0.46)* | − 5.50 (− 14.49, 3.49) | − 11.15 (− 21.56, − 0.75)* | .024* |
| Tb.Th (mm) | Ref. | 0.20 (− 0.27, 0.67) | 0.16 (− 0.41, 0.74) | 0.25 (− 0.42, 0.91) | .400 |
| Tb.Sp (mm) | Ref. | 8.98 (0.68, 17.29)* | 5.21 (− 4.91, 15.33) | 14.37 (2.66, 26.08)* | .014* |
| Ct.Po (%) | Ref. | 3.26 (− 16.09, 22.61) | 0.07 (− 23.57, 23.70) | 7.82 (− 19.55, 35.19) | .628 |
| Ct.Th (mm) | Ref. | − 3.10 (− 7.70, 1.51) | − 1.62 (− 7.24, 4.00) | − 5.21 (− 11.71, 1.30) | .117 |
| Ct.Po.Dm (mm) | Ref. | 3.41 (− 1.59, 8.41) | 2.24 (− 3.86, 8.34) | 5.08 (− 1.99, 12.14) | .136 |
| Biomechanical | |||||
| F.Ult (kN) | Ref. | − 0.15 (− 0.32, 0.02) | − 0.08 (− 0.28, 0.13) | − 0.26 (− 0.49, − 0.02)* | .038* |
| Scomp (kN/mm) | Ref. | − 2.47 (− 5.49, 0.55) | − 1.02 (− 4.69, 2.66) | − 4.55 (− 8.80, − 0.29)* | .045* |
| Tibia | No VF | VF (β (95% CI)) | Gr. 1 VF (β (95% CI)) | Gr. 2–3 VF (β (95% CI)) | P value for trend |
| vBMD | |||||
| Dtot (mgHA/cm3) | Ref. | − 21.35 (− 33.04, − 9.66)* | − 16.83 (− 31.23, − 2.42)* | − 27.58 (− 44.02, − 11.13)* | .000* |
| Dtrab (mgHA/cm3) | Ref. | − 16.55 (− 25.22, − 7.66)* | − 13.88 (− 24.70, − 3.05)* | − 19.96 (− 32.32, − 7.61)* | .000* |
| Dcort (mgHA/cm3) | Ref. | − 1.65 (− 19.28, 15.97) | 3.7 (− 18.26, 25.20) | − 8.69 (− 33.50, 16.12) | .637 |
| Micro-architecture | |||||
| Tb.N (1/mm) | Ref. | − 7.18 (− 13.69, − 0.67)* | − 6.81 (− 14.85, 1.22) | − 7.68 (− 16.85, 1.49) | .040* |
| Tb.Th (mm) | Ref. | − 0.28 (− 0.84, 0.27) | − 0.40 (− 1.09, 0.28) | − 0.12 (− 0.90, 0.66) | .479 |
| Tb.Sp (mm) | Ref. | 9.31 (1.92, 16.70)* | 8.74 (− 0.38, 17.86) | 10.09 (− 0.32, 20.50) | .018* |
| Ct.Po (%) | Ref. | − 8.90 (− 21.20, 3.39) | − 8.10 (− 23.28, 7.07) | − 10.00 (− 27.32, 7.33) | .167 |
| Ct.Th (mm) | Ref. | − 5.90 (− 11.69, − 0.11)* | − 4.49 (− 11.63, 2.65) | − 7.83 (− 15.99, 0.32) | .036* |
| Ct.Po.Dm (mm) | Ref. | 0.95 (− 2.71, 4.62) | 0.20 (− 4.32, 4.72) | 1.99 (− 3.17, 7.15) | .492 |
| Biomechanical | |||||
| F.Ult (kN) | Ref. | − 0.55 (− 0.90, − 0.21)* | − 0.47 (− 0.89, − 0.04)* | − 0.67 (− 1.15, − 0.18)* | .002* |
| Scomp (kN/mm) | Ref. | − 10.88 (− 17.56, − 4.21)* | − 9.20 (− 17.43, − 0.97)* | − 13.20 (− 22.59, − 3.80)* | .001* |
All analyses are adjusted for age, weight, height, type of recent non-vertebral fracture type (major osteoporotic fracture vs. other fractures), previous fractures at or above the age of 50 years, anti-osteoporosis medication (never vs. history vs. current), and femoral neck areal BMD
No prevalent VF is used as the reference group. *Significant
VF, vertebral fracture; Ref., reference; vBMD, volumetric bone mineral density; Dtot, total density; Dtrab, trabecular density; Dcort, cortical density; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; Ct.Th, cortical thickness; Ct.Po, cortical porosity; Ct.Po.Dm, cortical pore diameter; F.Ult, ultimate failure load; Scomp, compression stiffness