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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Trends Cancer. 2019 Apr 30;5(5):308–324. doi: 10.1016/j.trecan.2019.03.005

Figure 5. Impact of the RB1 pathway on cancer lineage plasticity and acquired therapeutic resistance.

Figure 5.

The figure depicts the increasingly appreciated effects of RB1 on epigenetic instability mediated by the cell cycle and pluripotency regulatory networks aberrantly re-activated in cancer. This epigenetic instability can facilitate adaptation of cancer cells to therapies targeting lineage specific dependencies (e.g. androgen receptor, EGFR, etc.). Points of possible therapeutic intervention to counter cancer lineage plasticity include activation of the RB1 when it is present or suppressing downstream effects of RB1 loss using epigenetic modulating drugs.