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. 2019 Sep 3;14:19. doi: 10.1186/s13015-019-0155-6

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Non-uniqueness of solutions in a multi-region lung cancer cohort of 100 patients [18]. a In this lung cancer cohort of 100 patients, 1 to 7 regional samples (y-axis) of each cancer have undergone bulk DNA sequencing, followed by the identification of mutations clusters (x-axis) using PyClone [34]. b This dataset exhibits extensive non-uniqueness of solutions (median of 3 solutions per patient). The number of solutions increased when downsampling the number m of bulk samples (color indicates the number of removed samples)