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. 2019 Aug 1;151(9):1116–1134. doi: 10.1085/jgp.201912327

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© 2019 Sato et al.

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Figure 10. — Feedback model for Ca_V1.2 cluster formation. (A) In silico images of Ca_V1.2 clusters at 0, 12, 24, 36, and 48 h after the initiation of expression. (B) Solutions to the feedback model equations $\frac{d P_{R}}{d t}$ , $\frac{d P_{g}}{d t}$ , and $\frac{d P_{n}}{d t}$ . (C and D) The black trace depicts the time course of mean cluster area (C) and density (D) of simulated Ca_V1.2 clusters. Colored dots represent the superimposed experimental data from Fig. 3. (E) Predicted mean Ca_V1.2 channel (black) and cluster dwell times (red) based on the feedback model.