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. 2019 Aug 1;151(9):1116–1134. doi: 10.1085/jgp.201912327

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© 2019 Sato et al.

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Figure 9. — Sigmoidal time-dependent changes in P_g, P_n, and P_R reproduce the time course of TRPV4 cluster formation in the plasma membrane of tsA-201 cells. (A) Plots of P_g,TRPV4 (purple), P_n,TRPV4 (orange), and P_R,TRPV4 (green) versus time. $P_{R, T R P V 4} = [1 / (1 + 10 e^{- 60 t})] * 0 .001166667$ , $P_{g, T R P V 4} = [1 / (1 + 15 e^{- 12 t})] * 0.07$ , and $P_{n, T R P V 4} = [1 / (1 + 75 e^{- 16 t})] * 0 .00045$ . (B) In silico images of TRPV4 clusters at 0, 12, 24, 36, and 48 h after the initiation of expression using the parameters in A. (C and D) The black trace depicts the time course of mean cluster area (C) and densities of simulated clusters (D). Colored dots represent the superimposed experimental data from Fig. 4. (E) Mean TRPV4 channel (black) and cluster (red) dwell times based on the sigmoidal functions P_g, P_n, and P_R.