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. 2019 Aug 13;151(9):1135–1145. doi: 10.1085/jgp.201912421

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© 2019 Pandhare et al.

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Figure 4. — SEC-MALS determination of oligomeric assembly. (A) Both the ICD (dotted black) and the Δ44 construct (purple line) maintain pentameric assembly, whereas deletions in the ΔMA (pink line) and the MA (orange line) constructs abolish pentamerization of the ICD. (B) The QDA substitutions (red line) disrupt the pentameric assembly of the ICD. A representative SEC-MALS profile showing the Rayleigh ratio. Note that different flow rates were used during the monitoring period for A (0.5 ml/min) and B (0.3 ml/min).