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. 2019 Jun 24;216(9):1986–1998. doi: 10.1084/jem.20190344

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Figure 4. — Immunophenotype of patients with IL6R mutations. (A) Percentages of IL-17A–producing (left) and IFNγ-producing (right) CD4⁺ T cells from healthy controls (HCs; n = 5), P1 (dark square), and P2 (blue circle) from two independent experiments. Black, data from experiment 1; blue, data from experiment 2. (B) Flow cytometry analysis of expression of markers found in pathological effector Th2 cells in CRTH2⁺ memory CD4⁺ T cells. Mann–Whitney U test; *, P < 0.05. (C) Flow cytometry analysis of blood CXCR5⁺ memory cTFHs in P1, P2, and healthy controls. (D) Flow cytometry assessment of B lymphocyte class switching and memory cell formation in P1, P2, and healthy controls and the healthy parents (HP). Error bars represent SEM.