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. 2019 Jul 16;216(9):2170–2183. doi: 10.1084/jem.20181953

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© 2019 Moser et al.

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Figure 5. — Itch limits B cell mTORC1 activity. (A and B) CD23⁺ FO B cells from WT and Itch KO mice were stimulated in vitro with (A) anti-IgM or (B) CpG for between 5 and 240 min. At the indicated times, P-S6 was detected by flow cytometry. Representative histograms and quantifications are shown. The mean fluorescence intensity (MFI) was quantified from the total population. The vertical line indicates the threshold for a positive P-S6 value (n = 5, compiled from three independent experiments, two-way ANOVA; error bars indicate SEM; WT mice were C57Bl/6 [CD45.2]). *, P < 0.05; **, P < 0.01; ****, P < 0.0001.