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. 2019 Aug 8;218(9):2919–2944. doi: 10.1083/jcb.201902117

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© 2019 Bertero et al.

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Figure 4. — Gene expression changes in lamin A/C haploinsufficient hiPSC-CMs. (A) RT-qPCR analyses in hiPSC-CMs at day 14 of differentiation. Differences versus mutant were calculated by one-way ANOVA with post hoc Holm–Sidak binary comparisons (*, P < 0.05; n = 3 differentiations; average ± SEM). (B) Hierarchical clustering of hiPSC-CMs analyzed by RNA-seq based on all expressed genes. r, replicate. (C) Overlap in genes up- or down-regulated in mutant hiPSC-CMs versus hiPSC-CMs from the two corrected control lines (change greater than twofold and q-value <0.05; Table S2). (D) Selected results from gene ontology (GO) and pathway enrichment analyses of genes consistently up- or down-regulation in mutant hiPSC-CMs. KEGG, Kyoto Encyclopedia of Genes and Genomes. (E) Linear dimensionality reduction by principal component (PC) analysis of RNA-seq data of mutant and corrected hiPSC-CMs, and hESC-CMs sampled at different time points of differentiation.