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. 2019 Apr 15;28(7):973–979. doi: 10.1177/0963689719842162

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig 1. — Generation and assessment of humanized mice. (A) Operation of intra-bone marrow injection. (B) Assessment of percent survival of humanized mice. Six humanized mice in each group were monitored weekly. (C) Differentiation of human CD45+ and CD19+ cells in each groups at 4 weeks post-transplantation (wpt). D. the significant difference between control and busulfan groups in the ratio of hCD45 to mCD45 and percentage of human lymphocytes subsets at 4 wpt. **P < 0.01, Data are mean ± SEMs in humanized mice (n = 6, each group).