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. 2019 Aug 21;10:1923. doi: 10.3389/fmicb.2019.01923

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Copyright © 2019 Caimano, Groshong, Belperron, Mao, Hawley, Luthra, Graham, Earnhart, Marconi, Bockenstedt, Blevins and Radolf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of the rpoS-complementing plasmid by ΔrpoS B. burgdorferi is associated with production of antibodies against OspA and BBA62 in mice. ELISA assay performed using sera collected from individual C3H/HeJ mice and purified recombinant proteins for tick-phase gene products (OspA and BBA62) repressed by RpoS in mammals (A) and genes products upregulated (OspC and DbpA) or unaffected (FlaB) by RpoS (B). Sera was collected at the designated time points (in weeks) following syringe-inoculation with either WT+empty vector (BbP1974) or rpoScomp (BbP1754). Columns represent the average and standard error of the mean from three mice per strain, per time point (4- to 20-weeks). p-Values for pairwise comparisons (WT vs. rpoScomp) were determined using a two-tailed t-test. ^∗p ≤ 0.05; ^∗∗p ≤ 0.001; ^∗∗∗p ≤ 0.0001.