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. 2019 Aug 27;10:1967. doi: 10.3389/fimmu.2019.01967

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Copyright © 2019 Shathili, Bandala-Sanchez, John, Goddard-Borger, Thaysen-Andersen, Everest-Dass, Adams, Harrison and Packer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sialic linkage analysis of active monoQ active fractions. (A) EICs of the di-sialylated N-glycan m/z 1111.4²⁻ after sequential α-2,3 sialidase treatment of bovine fetuin, known to carry tri-antennary α-2,3-sialylated N-glycans. The EICs assess the removal of each of the sialic acid residues. (B) Summed MS of all N-glycans observed for the active CD52 fractions F48 and F49 before (i) and after treatment with α-2,3-specific sialidase (ii). (C) Summary of the degree of α-2,3 sialylation and bisecting GlcNAcylation of late-eluting MonoQ fractions of particular interest. (D) High-resolution intact mass analysis of the immune suppressive CD52 fractions (F48/F49).