Table 1.
Analysis of Hydrogen Bonding Interaction Patterns in the STAT3-STAT3 Dimer and in the STAT3-DAPK-STAT3 Complex
| STAT3-STAT3 |
STAT3-DAPK-STAT3 |
||
|---|---|---|---|
| STAT3 |
STAT3 |
STAT3 |
STAT3 |
| Monomer 1 | Monomer 2 | Monomer 1 | Monomer 2 |
| Glu 638 | Asn 664 | Arg 414∗ | Pro 639, Glu 638, Gln 644 |
| Asn 647 | Lys 709 | Arg 417∗ | Tyr 640, Thr 714, Cys 712, Val 713 |
| Ser 649 | Thr 708 | Glu 415 | Tyr 640 |
| Ser 649 | Leu 706 | Ser 465 | Pro 715 |
| Glu 652 | Thr 708 | Gln 416 | Asn 647 |
| Arg 688 | Leu 706 | Asn 385 | Gln 644, Asn 647 |
| Leu 706 | Glu 652, Phe 710, Cys 712 | Gln 469 | Phe 716 |
| Arg 423 | Leu 666 | ||
| Asp 374 | Thr 708 | ||
| Asn 420 | Glu 652, Lys 709, Met 655 | ||
| Arg 379 | Lys 709 | ||
∗
Arg414 and Arg417 are required for nuclear translocation of STAT3.