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. 2019 Jul 15;3(9):1191–1204. doi: 10.1002/hep4.1395

Figure 4.

Figure 4

LXR agonist T09 alone restores ABCA1 and attenuates inflammatory and fibrogenic markers independently from PPARγ in HSCs with the PNPLA3 I148M variant. LX‐2 stable overexpressing WT or I148M PNPLA3 untreated or treated for 24 hours with either T09 (+T09) or the combination T09 and ROSI (+T09+Rosi). mRNA expression of (A) ABCA1, (B) collagen1α1, (C) PPARγ1 and (D) CCL5 and analyzed by RT‐PCR and normalized to 18s. White bars show untreated HSCs, gray bars show HSCs treated with T09, and black bars show HSCs treated with T09 or the combination (+T09+Rosi). All bar graphs show mean values ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001 versus untreated WT or I148M HSCs (n = 3 for each genotype).