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. 2019 Jul 10;3(9):1235–1249. doi: 10.1002/hep4.1404

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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FFC‐fed female mice develop liver injury. (A) Body weight of FFC‐fed female mice (n = 5‐8 per group) showed significantly elevated body weights from week 10 onwards compared with RCD mice (n = 7‐8 per group). (B) FFC‐fed mice had significantly higher relative liver mass at weeks 10, 24, 36, and 60 (n = 7‐8 per group). (C) FFC‐fed mice had significantly elevated ALT levels compared with RCD mice from weeks 10 to 60 (n = 4‐8 per group), while the ALT levels of RCD mice were stable and low. Data represent mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001.