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. 2019 Jul 10;3(9):1235–1249. doi: 10.1002/hep4.1404

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Histologic images of NASH in FFC‐fed female mice. Representative images of hematoxylin and eosin‐stained hepatic sections (both RCD‐fed and FFC‐fed mouse samples at all time points). Original magnification ×20; n = 5‐8 per group. The rapid onset of steatosis was observed in FFC‐fed mice at week 1 (grade 1; 62.5%, 5/8). Steatosis developed progressively afterwards; most FFC‐fed mice showed severe steatosis (grade 3) at week 36 (75%, 6/8) and week 60 (60%, 3/5). FFC‐fed mice demonstrated mild ballooning from week 16 (grade 1; 25%, 2/8); more mice developed mild ballooning afterwards and kept grade 1 ballooning until their endpoint at week 60. No steatosis or ballooning was observed in RCD‐fed mice at any time point.