Figure 5.

Absence of SLP blunts the intraocular infiltration of PMN during Bacillus endophthalmitis. C57BL/6J mouse eyes were injected with 100 CFU WT or ΔslpA B. thuringiensis. At 4, 8, and 12 hours postinfection, infected eyes were harvested and infiltration of PMN was assessed by quantifying MPO in whole eyes by sandwich ELISA. MPO levels were significantly greater in eyes infected with WT strains at 4, 8, and 10 hours postinfection compared with the eyes infected with ΔslpA B. thuringiensis. Values represent the mean ± SEM of MPO (ng/eye) of N ≥ 4 per time point for at least two separate experiments. *P = 0.0095; **P = 0.0022; ***P = 0.0043.