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. 2019 Jul 19;3(9):1205–1220. doi: 10.1002/hep4.1396

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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IL32 protein expression in liver biopsies from Cont and Ob_NASH patients and effect of recombinant IL32 on insulin signaling in PHHs. (A) Immunoblots of protein extracts from patients with NASH and control liver biopsies showing an increase in IL32 expression in NASH. (B) Recombinant IL32 treatment induces decreased insulin signaling in protein lysates from PHHs as demonstrated by the robust decrease in AKT^T308 phosphorylation after insulin stimulation. Abbreviations: Cont, controls; NT, nontreated; *, non specific.