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. 2019 Aug 30;15:2537–2550. doi: 10.2147/NDT.S210340

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© 2019 Correll et al.

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Plasma concentrations of total CAR^a after discontinuation.

Notes: ^aGeometric mean values (geometric SD) of model-predicted total CAR (combined cariprazine, DCAR, and DDCAR) plasma concentrations in patients randomized to placebo during double-blind period; these predicted values are in line with observed data from a pharmacokinetic clinical study^;17 ^bEC₅₀ values for D₂ and D₃ receptor occupancy were obtained from Girgis et al (2016)^.40

Abbreviations: DCAR, desmethyl-cariprazine; DDCAR, didesmethyl-cariprazine; total CAR, combined cariprazine, DCAR, and DDCAR.