Figure 5.

Mesenchymal stem cell regulation of the lung fibrotic microenvironment. MSCs protect radiation-injured lungs against ROS secreting superoxide dismutase enzymes and reduce inflammatory signaling, inhibiting immune cell activation by the release of immunosuppressive cytokines. They also limit fibrotic response by reducing myofibroblast differentiation from epithelial cells and fibroblasts and ECM deposition [6,15,28,46,114,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195,196,197,198,199,200].