Bakri 2015.

Methods	RCT comparing the efficacy of dexmedetomidine, ondansetron, and haloperidol for treatment of postoperative delirium Study took place in a single 24‐bed ICU (mixed medical and surgical) in Saudi Arabia
Participants	Participants included 96 (N = 32 dexmedetomidine, mean age 31 ± 4 years, 29/32 (91% male); N = 32 ondansetron, mean age 32 ± 5 years, 30/32 (94%) male, N = 32 haloperidol, mean age 30 ± 7 years, 28/32 (88%) male) critically ill trauma patients diagnosed with postoperative delirium (ICDSC score ≥ 4) Study enrolment between 2011 and 2013
Interventions	Participants received 1 μg/kg dexmedetomidine, 4 mg ondansetron, or 5 mg haloperidol, administered as a continuous intravenous infusion over 20 minutes. Study drug was started after delirium was diagnosed and was given twice daily for 3 consecutive days Treating physicians were allowed to prescribe rescue haloperidol for all groups Assessment: ICDSC was administered twice daily Non‐drug strategies: not reported
Outcomes	Primary outcome (measured day 3) Number of patients with delirium Secondary outcomes (measured day 3) Number of patients requiring rescue haloperidol Mean dose of rescue haloperidol
Notes	Funding The study was carried out without external funding Registration No trial registration number was included in the manuscript
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Participants were randomly allocated to 3 equal groups according to a computer‐generated random numbers sequence
Allocation concealment (selection bias)	Unclear risk	Method of concealment was not reported and was not available from study authors
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Study medications were prepared by physicians who were not part of the research team. All study drug was administered as a continuous infusion over a 20‐minute period to maintain blinding
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Data were collected by researchers blinded to study allocation. Participants were managed by ICU staff not included in the study. ICU nurses conducted delirium assessments as part of the standard of care
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No flow chart was included to report numbers of screened vs randomized participants
Selective reporting (reporting bias)	Unclear risk	All outcomes reported in methods were included in results. Data presented for all participants were included in the analysis. However without a published protocol or trial registration, it is unknown if all outcomes were reported as planned
Other bias	Unclear risk	All participants were permitted rescue haloperidol. Use of rescue haloperidol was an outcome Sample size calculation was not reported