Schoeffler 2012.

Methods	Randomized trial comparing clonidine vs placebo in the treatment of delirium Single centre in the USA
Participants	Adult (> 18 years) trauma patients admitted to the ICU > 24 hours, meeting criteria for extubation, declared stable from a neurological, respiratory, and cardiovascular standpoint to receive clonidine, and diagnosed with delirium via the CAM‐ICU
Interventions	Participants received an oral loading dose of 0.3 mg clonidine or matched placebo, along with a transdermal clonidine patch of the same dose with patch overlay (patch overlay alone in placebo group). 12 hours later, a final dose of 0.3 mg clonidine or matched placebo was given
Outcomes	Primary Duration of mechanical ventilation Secondary Incidence and duration of delirium, time to successful spontaneous breathing trial
Notes	Study is stated as terminated in June 2017 due to difficulty recruiting participants . Study was started in May 2010 and was registered under the name "A randomized double blinded placebo controlled trial of transdermal clonidine for adjuvant sedation in ventilated trauma patients experiencing delirium" Interim study results published in abstract form (Schoeffler 2012) Sponsor: Memorial Health University Medical Center (Savannah, Georgia) Study registered: at clinicaltrials.gov under NCT01139996 Principal investigator was contacted and was not able to share data for inclusion in this review (schoeme1@memorialhealth.com)

CAM‐ICU: Confusion Assessment Method for the ICU.

ICU: intensive care unit.

RASS: Richmond Agitation‐Sedation Scale.