Table 7.
Situation | Method | Model | Knot | Mean | SD | Median | 95% Bayesian CI |
---|---|---|---|---|---|---|---|
(P25-P75) | |||||||
No prior constraints | Bayesian probabilistic constraint model | NP | Se 1 | 0.626 | 0.218 | 0.665 | 0.516-0.773 |
Sp 1 | 0.369 | 0.217 | 0.330 | 0.222-0.476 | |||
Se 2 | 0.490 | 0.167 | 0.495 | 0.391-0.585 | |||
Sp 2 | 0.508 | 0.167 | 0.503 | 0.414-0.616 | |||
p | 0.498 | 0.248 | 0.497 | 0.305-0.692 | |||
Conditional Covariance Bayesian model |
NC | Se 1 | 0.690 | 0.183 | 0.708 | 0.622-0.807 | |
Sp 1 | 0.435 | 0.226 | 0.390 | 0.287-0.568 | |||
Se 2 | 0.547 | 0.197 | 0.535 | 0.455-0.657 | |||
Sp 2 | 0.571 | 0.213 | 0.562 | 0.444-0.722 | |||
p | 0.553 | 0.254 | 0.578 | 0.366-0.755 | |||
| |||||||
Prior constraints | Bayesian probabilistic constraint model | PP | Se 1 | 0.713 | 0.036 | 0.714 | 0.689-0.738 |
Sp 1 | 0.423 | 0.051 | 0.421 | 0.387-0.456 | |||
Se 2 | 0.535 | 0.025 | 0.535 | 0.518-0.552 | |||
Sp 2 | 0.537 | 0.022 | 0.537 | 0.522-0.552 | |||
p | 0.538 | 0.042 | 0.539 | 0.510-0.567 | |||
Conditional Covariance Bayesian model |
PC | Se 1 | 0.904 | 0.037 | 0.907 | 0.881-0.931 | |
Sp 1 | 0.796 | 0.119 | 0.814 | 0.715-0.892 | |||
Se 2 | 0.588 | 0.055 | 0.580 | 0.551-0.614 | |||
Sp 2 | 0.677 | 0.068 | 0.677 | 0.631-0.723 | |||
p | 0.649 | 0.076 | 0.662 | 0.608-0.701 |
Se 1: sensitivity of T-SPOT; Sp1: specificity of T-SPOT; Se2: sensitivity of KD38; Sp2: specificity of KD38; p: prevalence within the patients in the study; SD: standard deviation; CI: confidence interval.